# Investigation of bacterial involvement in canine CRGV cases

> Contract award record from UK public-sector procurement sources.

## Key facts

- Public buyer: Defra Network eTendering Portal
- Contract winner: [University of Bristol,](/contract-winners/university-of-bristol/public-sector-contract-awards)
- Award value: £25,000
- Award date: 10 February 2020
- Published: 20 April 2020
- Contract start: 1 November 2019
- Contract end: 31 March 2020
- Stage: awarded
- Procurement category: services
- Notice ID: 6e222e4d-4d48-4081-b335-053e0aba96d7-354841
- OCID: ocds-b5fd17-ec9dc124-696d-441a-9f42-c16ffe0310fe

## Description

Canine cutaneous and renal glomerular vasculopathy \(CRGV and sometimes known as 'Alabama rot'\) in the UK first appeared in 2012, with 4 cases presenting to a Anderson Moores from practices around the New Forest, Hampshire with acute kidney injury \(AKI\) and skin lesions\. The numbers of cases and geographical distribution of the disease have in the main increased year on year, with 190 cases now reported\. The disease is normally characterised by the initial appearance of skin lesions on the limbs \+/- face and body\. Some dogs then go on to develop acute deterioration of kidney function and death\. On post mortem blood vessels are seen to be blocked by thrombi \(clots\)\. The cause of the disease is unknown, despite investigation\. Tests undertaken include investigation for E\.coli \(given some similarities to human haemolytic uremic syndrome\), Circovirus, pan viral metagenomics and bacterial 16S probes, heavy metals and ethylene glycol poisoning\. Leptospira has been investigated as a cause, and although presence of this organism was high in cases, results couldn't indicate a causative link\. Despite the extensive investigations already undertaken, a few bacterial causes remain possible based upon experimental results or pathological findings\. Toxigenic bacteria have not been found in the kidneys, but this does not rule out their presence in the skin lesions, with local production of toxins into the circulation causing subsequent kidney injury\. Shiga toxigenic E\. coli were hypothesised to cause similar disease in the USA with kidney injury\. Aeromonas hydrophilia causes similar skin lesions in fish and amphibians with subsequent kidney failure, as well as disease in humans, and are also toxigenic, with toxin production in limbs causing organ injury\. Leptospira were unusually prevalent in cases and can cause kidney injury\. Without an analysis of cases vs healthy animals it is impossible to confirm the likely association of these bacteria \(Aeromonas, E\.coli and Leptospira Additional information: Please note that Defra procurement uses an E-tendering system for Procurement activities\. This is currently provided by Bravo Solutions\. To access appropriate tendering and contractual documents, please access the E-Tendering portal at https://defra\.bravosolution\.co\.uk", ensuring that your registration includes "Defra"\. If you have any problems with this system, please contact Bravo on their telephone helpline number 0800 368 4850 or by emailing them at help@bravosolution\.co\.uk\. "

## Related contract awards

- [National EA Estates Professional Surveying Framework](/contracts/ocds-b5fd17-9191aaea-5356-4bdc-a3e1-af6b3670e583): Defra Network eTendering Portal
- [Parliamentary Monitoring Service](/contracts/ocds-b5fd17-a6ea66bd-b313-46f9-a02a-2c5007aa1856): Defra Network eTendering Portal
- [Provision of Geological Products](/contracts/ocds-b5fd17-8d85b0c1-45ff-4562-9d99-6009685196de): Defra Network eTendering Portal
- [RDE808: Animal Abuse and Domestic Homicide/Suicide](/contracts/ocds-b5fd17-c026c8af-fb1e-45a4-8c8b-82ac551c2f20): Department for Environment, Food & Rural Affairs
- [PDRA for Additive manufacture of fuels in support of the Uranics Innovation Programme](/contracts/ocds-b5fd17-0697bcee-c16a-4fa6-8892-4f21b4fe4b54): NATIONAL NUCLEAR LABORATORY LIMITED
- [PhD Studentship Developing a Welfare Assessment Protocol for Kennelled Dogs](/contracts/ocds-b5fd17-8e603c45-dafd-458d-8560-4ea539885c06): Dept for Environment, Food and Rural Affairs

## Source

[View the original notice on Contracts Finder](https://www.contractsfinder.service.gov.uk/Notice/6e222e4d-4d48-4081-b335-053e0aba96d7-354841)